But their high hopes for happiness are dashed when their charter boat captain dumps them off at the wrong island—and even worse, it's deserted. Rick and Dean must try to survive until the captain's scheduled return in six days. Curiously, Rick's discovery of some unusual berries leaves him in a highly unusual condition—he's become invisible.

What ensues is a hilarious story of Rick's struggle to cope with his newfound “talent.” When the brothers return to their hometown of Vaglooshi, Mississippi, Rick seeks new ways to make himself useful around town. He manages to slip onto a movie set, befuddle a college quarterback, thwart an attempted robbery, and convince a street beggar to clean up and find a job. But Dean finds a better use for Rick's invisibility than mischief. An illegal drug is circulating the streets, and Dean needs Rick's special ability to help him crack the case.